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PEER REVIEWED ARTICLES FROM HBM4EU

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
Elina Drakvik, Rolf Altenburger, Yasunobu Aoki, Thomas Backhause, Tina Bahadori, Robert Barouki, Werner Brack, Mark T.D. Cronin, Barbara Demeneix, Susanne HougaarD Bennekou, Jacobvan Klaveren, Carsten Kneuer, Marike Kolossa-Gehring, Erik Lebret, Leo Posthuma, Lena Reiber, Cynthia Rider, Joëlle Rüegg, Giuseppe Testa, Bart van der Burg, Hilkovan der Voet, A. Michael Warhurst, Bob van de Water, Kunihiko Yamazaki, Mattias Öberg, Åke Bergman 11/2019
Deciphering adverse outcome pathway network linked to Bisphenol F using text mining and systems toxicology approaches
Marylène Rugard, Xavier Coumoul, Jean-Charles Carvaillo, Robert Barouki, Karine Audouze 10/2019
Cadmium Exposure and Risk of Breast Cancer by Histological and Tumor Receptor Subtype in White Caucasian Women: A Hospital-Based Case-Control Study
Loreta Strumylaite, Rima Kregzdyte, Algirdas Bogusevicius, Lina Poskiene, Dale Baranauskiene and Darius Pranys 06/2019
A strategy to validate a selection of human effect biomarkers using adverseoutcome pathways: Proof of concept for phthalates and reproductive effects
Kirsten Baken, Nathalie Lambrechts, Greet Schoeters, et al. 05/2019
Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future
Henriqueta Louro, Tiina Santonen, et al. 05/2019
Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach
Jean-Charles Carvaillo, Robert Barouki, Xavier Coumoul and Karine Audouze 04/2019
Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways
Lola Bajard, Lisa Melymuk and Ludek Blaha 02/2019
Physiology-based toxicokinetic modeling in the frame of the European Human Biomonitoring Initiative
Sarigiannis, D.A., Karakitsios, S., Dominguez-Romero, E., Papadaki, K., Brochot, C., Kumar, V., Schumacher, M., Sy, M., Mielke, H., Greiner, M., Mengelers, M., Scheringer, M. 01/2019
Current EU research activities on combined exposure to multiple chemicals
Stephanie K. Bopp et. al, 08/2018
Development of Policy Relevant Human Biomonitoring Indicators for Chemical Exposure in the European Population
Jurgen Buekers et. al 09/2018
Human biomonitoring as a tool to support chemicals regulation in the European Union
Catherine Ganzleben et. al, 01/2017
Special Issue „Human Biomonitoring 2016“
Gerda Schwedler et. al 03/2017
Human biomonitoring in Israel: Recent results and lessons learned
Tamar Bermana et. al, 12/2017

PEER REVIEWED ARTICLES WITH REFERENCE TO HBM4EU

Deliverable 8.1 Description of the national programmes - a strategy to collect EU wide HBM data
Greet Schoeters (VITO) et al. 04/2018
Deliverable 7.3 1st prioritisation Report on survey design: Study protocols, SOPs and Guidelines, tailored and transferred questionnaires for recruitment and sampling
Ulrike Fiddicke (UBA) et. al, 02/2018
Deliverable 5.2 1st substance-group specific derivation of EU-wide health-based guidance values
Petra Apel (UBA) et. al, 12/2017
Additional Deliverable AD 8.2 Research plan for chromates study under HBM4EU
Sophie Ndaw (INRS) et. al, 01/2018
Deliverable 7.2 Strategy and SOPs for human sample exchange, including ethical demands
Dominik Lermen (IBMT) et. al, 12/2017
Deliverable 7.1 Report on ongoing activities and existing data and data gaps for the 1st prioritised substances including a list of metadata that can be uploaded in IPCheM
Ana Virgolino (FMUL) et. al, 12/2017
Deliverable 10.2 Statistical Analysis Plan
Martine Vrijheid (ISGlobal) et. al, 12/2017
Deliverable 5.3 Scoping paper on the development of an indicator on chemical exposure in the European population
Xenia Trier (EEA) et. al, 12/2017
Deliverable 12.2 Report on the optimal methodology for exposure reconstruction from HBM data
Milena Horvat (JSI) et. al, 12/2017
Additional Deliverable 16.3 Direct effect based approaches applied to the screening of emerging substances
Marja Lamoree (VU-IVM) et. al, 12/2017
Additional Deliverable 16.1 Screening methods inventory
Mariane Pourchet-Gellez (INRA) et. al, 12/2017
Deliverable 16.1 Prioritised list of known emerging chemicals
Jelle Vlaanderen (IRAS) et. al, 12/2017
Additional Deliverable 15.3 HBM mixture database description and proposal statistical analysis plan
Jelle Vlaanderen (IRAS) et. al, 12/2017
Additional Deliverable 5.1 A (phased) plan for action: how structurered multi-actor dialogues on human biomonitoring results can facilitate targeted policy action (generic canvas for HBM4EU)
Ann Crabbé (UAntwerpen) et. al, 12/2017
Deliverable 2.4 2018 Programme of training activities, materials and capacity building mechanisms
Paul T.J. Scheepers (RUMC) et. al, 12/2017
Deliverable 5.1 Human biomonitoring in risk assessment: analysis of the current practice and 1st examples on the use of HBM in risk assessments of HBM4EU priority chemicals
Tiina Santonen (FIOH) et. al, 11/2017
Deliverable 9.4 The Quality Assurance/Quality Control Scheme in the HBM4EU project
Thomas Göen (IPASUM) et. al, 11/2017
Additional Deliverable 11.1 How can the results from BRIDGE Health be incorporated to the work of HBM4EU?
Madlen David (UBA) et. al, 10/2017
Additional Deliverable 12.1 Database of exposure-related and ancillary data for priority substances
Alberto Gotti (IUSS) et. al, 10/2017
Deliverable 9.3 Database of candidate laboratories for the 1st prioritisation round of substances
Octavio Pérez Luzardo (ULPGC) et. al, 10/2017
Deliverable 2.3 2018 Strategy for the communication and dissemination of HBM4EU results
Catherine Ganzleben (EEA) et. al, 10/2017
Deliverable 14.1 Criteria for prioritisation of biomarkers of effect
Nicolás Olea (UGR) et. al, 10/2017
Additional Deliverable 11.2 Criteria for feasibility studies
Hanna Tolonen (THL) et. al, 09/2017
Deliverable 1.8 Establishment of Stakeholder Forum and Advisory Board
Lena Reiber (UBA) et. al, 09/2017
Deliverable 9.2 Prioritised list of biomarkers, matrices and analytical methods for the 1st prioritisation round of substances
Cathrine Thomsen (NIPH) et. al, 09/2017
Deliverable 4.3 Prioritisation strategy and criteria
Jean-Nicholas Ormsby (ANSES) et. al, 08/2017
Additional Deliverable 12.2 Roadmap for model PBTK/D model refinement and analysis for priority substances
Laurent Bodin (ANSES) et. al, 08/2017
Additional Deliverable 12.1 Database of exposure-related and ancillary data for priority substances
Alberto GOTTI et. al, 07/2017
Deliverable 10.1 Data Management Plan, July 2017
Sylvie Remy (VITO) et. al, 07/2017
Annex to Deliverable 10.1 Data Policy, July 2017
Sylvie Remy (VITO) et. al, 07/2017
Additional deliverable 8.1 Report on access to occupational data
Tiina Santonen (FIOH) et. al, 06/2017
Deliverable 13.1 Criteria for the selection of cohort studies, June 2017
Thorhallur Ingi Halldorsson (UI) et. al, 06/2017
Deliverable 6.1 First set of key indicators for HBM4EU, June 2017
Hans Reynders et. al, 06/2017
Deliverable 4.2 Scoping documents on HBM4EU priority substances for 2018, June 2017
Greet Schoeters (VITO) et. al, 06/2017
Deliverable 4.1 Template for the submission of rapid requests, May 2017
Jean-Nicolas Ormsby (ANSES) et. al, 05/2017
Deliverable 9.1 Criteria for the prioritisation of biomarkers, April 2017
Loïc Rambaud (ANSP) et. al, 04/2017
Deliverable 2.1 HBM4EU Website, March 2017
Catherine Ganzleben and Derya Ay (EEA) 03/2017
Deliverable 2.2 Strategy for the communication and disseminatoin of HBM4EU results, March 2017
Catherine Ganzleben (EEA) 03/2017
Deliverable 1.2 Establishment of Governing Board, February 2017
Ulrike Doyle (UBA) et. al, 02/2017
Grant Agreement, November 2016
Number: 733032 11/2016
Deliverable 1.2 Establishment of the HBM4EU Governing Board
Ulrike Doyle (UBA) et. al, 03/2017

OTHER ARTICLES, NEWSLETTERS & BLOGS

Chemical mixtures pose ‘underestimated’ risk to human health say scientists
Marike Kolossa-Gehring 05/2019
RECETOX Newsletter
Research Centre for Toxic Compounds in the Environment (RECETOX) 11/2018
ECHA Newsletter 2017 - Issue 3
European Chemicals Agency 09/2017
European Union research in support of environment and health: Building scientific evidence base for policy
Tuomo Karjalainen et. al, 04/2017
Informationsplattform IPCheM: Zentraler Zugang zu Daten des Chemischen Monitorings in Europa
Gerlinde Knetsch and Maria Rüther, UMID 01/2017
Workshop Report HBM4EU: Nordic workshop for scientists and regulatory agencies discussing HBM4EU - the European human biomonitoring initiative
Knudsen, Lisbeth E. and Hansen, Pernille Winton 08/2017
Human biomonitoring: a cornerstone for environment and health policies
Maria João Silva 11/2016
Human biomonitoring: Science and policy for a healthy future, April 17–19, 2016, Berlin, Germany
Anke Joas et. al, 03/2017
Bringing together raptor collections in Europe for contaminant research and monitoring in relation to chemicals regulations
Paola Movalli et. al, 09/2017
The current status of exposure-driven approaches for chemical safety assessment: A cross-sector perspective
Fiona Sewell et. al, 08/2017
Life cycle-based health risk assessment of plastic waste
D.A. Sarigiannis et. al, 12/2017
Ikke-regulerede flammehæmmere i indeklimaet – nye eksponerings- og sundhedsrisici?
Katrin Vorkamp et. al, 12/2017
Human Biomonitoring: Die Umwelt in unserem Koerper
Oekoskop 12/2017
The added value of a surveillance human biomonitoring program: The case of FLEHS in Flanders (Belgium)
Hans Reynders et. al, 03/2017
Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach
Gerda Schwedler et al. 06/2017
Advancing environmental health surveillance in the US through a national human biomonitoring network
Megan Weil Latshaw et. al, 03/2017
Guest blog from the European Environment Agency (EEA): Human Biomonitoring for Europe
Health and Environment Alliance 11/2017

CALENDAR | Apr 2020

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Enrieco (Environmental Health Risks in European Birth Cohorts)
Enrieco (Environmental Health Risks in European Birth Cohorts) is a project conducted within the European Union's 7th Framework Programme [Theme 6, Environment (Including Climate Change)]. Its overall aim is to advance our knowledge on specific environment and health causal relationships in pregnancy and birth cohorts by providing support to exploitation of the wealth of data generated by past or ongoing studies funded by the EC and national programmes.
Environment and Health Information System (ENHIS)
ENHIS is an evidence-based information system aiming to support public health and environmental policies in the WHO European Region. The system is an interactive database, composed of country-level indicators and regional assessments (fact sheets).
EHES
European Health Examination Survey (EHES) is an initiative to set up a system of standardized, representative health examination surveys (HES) of the adult population of the European countries.
E-DOHaD
Environmentally-induced Developmental Origins of Health and Disease project aims to characterize the impact of environmental exposures on childhood health with focus on two families of pollutants with a highly prevalent and controllable exposure in humans: atmospheric pollutants and specific high-volume non-persistent chemicals (Bisphenol A, other phenols and phthalates).
EDC-MIXRISK
This EU project focuses on the effects of mixtures of endocrine disruptive chemicals on children. The aim is to promote safer use of chemicals for the next generation.
ECHEMNET
The European Chemical Emergency Network aims to set up an EU-level network of expert chemical health risk assessors who have experience in dealing with the acute phase of chemical incidents, ensure that experience of, and best practices adopted by, one Member State following an incident benefit other Member States and enable an efficient and coherent EU-level response to potentially devastating cross-border events through the consistent use of RASCHEM.
DENAMIC
Developmental neurotoxicity assessment of mixtures in children.
DEMOCOPHES
In DEMOCOPHES, 17 European countries tested a common approach for human biomonitoring surveys which was developed by COPHES. They produced data on the distribution of specific biomarkers and related lifestyle data among defined study populations which, for the first time, are comparable on a European scale. DEMOCOPHES aims at testing “the hypothesis that HBM can be performed in a coherent and harmonised manner throughout Europe, by means of commonly developed protocols, strategies and scientific tools, ensuring reliable and comparable data, whilst also leading to a more effective use of resources”.
DEER
Developmental Effects of Environment on Reproduction: EU funded project under framework 7 (FP7/2007-2013). It is a multidisciplinary research project aiming at improving our understanding of the role of environmental factors in the development and establishment of human reproductive health.
CYTOTHREAT
CytoThreat addresses the need to assess the risks of pharmaceuticals released in the environment, focusing on cytostatic drugs because they are highly hazardous compounds due to their genotoxic properties which may cause unexpected long term effects.
CROME
Introduction
The main environmental problem targeted by CROME-LIFE is the assessment of the impact on human health due to exposure to chemical agents originating either from environmental contamination (air, soil, water), or from consumer products (food contact materials, construction materials, cosmetics, clothes, etc.) through multiple routes, namely inhalation, ingestion and dermal contact in five distinct areas of southern Europe (Greece, Croatia, Slovenia, Italy and Spain).
COSMOS
This project addresses the safety assessment needs of the cosmetics industry, without the use of animals. The main aim of COSMOS is to develop freely available (open access and/or source) tools and workflows to predict the safety to humans following the use of cosmetic ingredients.
COPHES
COPHES is the Consortium to Perform Human Biomonitoring on a European Scale. Funded by the EU's Seventh Framework Programme, COPHES developed harmonised protocols allowing the collection of comparable HBM data throughout Europe. Its twin project, the feasibility study DEMOCOPHES, was launched one year later to test this hypothesis and to win information on levels and major determinants of exposure in Europe, as well as to establish protocols for the translation of HBM results into concrete policy recommendations.
CONTAMED
CONTAMED: Contaminant mixtures and human reproductive health – novel strategies for health impact and risk assessment of endocrine disrupters. CONTAMED aims to explore the hypothesis that combined exposure to endocrine disrupting chemicals in fetal life may lead to adverse delayed impacts on human reproductive health. To achieve this goal, CONTAMED will combine epidemiological approaches with laboratory science.
CITI-SENSE
CITI-SENSE works on development of sensor-based Citizens' Observatory Community for improving quality of life in cities. The project focuses on direct engagement of citizens within the fields of air quality, environmental quality of public spaces in cities and indoor air quality in schools. Funded by the EU's Seventh Framework Programme, 2010-2016, CITI-SENSE aims to empower citizens to contribute to and participate in environmental governance, to support and influence community and societal priorities and associated decision making.
CHICOS
Developing a Child Cohort Research Strategy for Europe - CHICOS is a project conducted within the European Union’s 7th Framework Programme. It's overall aim is to improve child health across Europe by developing an integrated strategy for mother-child cohort research in Europe.
ChemScreen
ChemScreen aims to provide practical solutions within the tight framework of REACH. The focus of the project is on the generation of a simple, rapid screening system for reproductive toxic chemicals, aiming at widespread implementation within the tight time schedule of the REACH program.
The CARBOTRAF
This project aims to realize a method, system and tools for adaptively influencing traffic in real-time. The project aims to reduce carbon dioxide CO2 and black carbon (BC) emissions caused by road transport in urban and inter-urban areas.
Bridge-Health
Bridging Information and Data Generation for Evidence-based Health policy and research. The BRIDGE Health project aims to prepare the transition towards a sustainable and integrated EU health information system for both public health and research purposes.
A-TEAM
Developing advanced tools for exposure assessment and biomonitoring.
ACROPOLIS
ACROPOLIS contributes to the development of a methodology to ensure that the missing aspects in the risk assessment of pesticides can be addressed in future risk management. This will increase trust of the consumer in safety regulation of pesticides.
ARCRISK
Focusses on impacts on health in the Arctic and in Europe resulting from climate-induced changes in contaminant cycling.
European, Middle Eastern, and African Society for Biopreservation and Biobanking
ESBB’s mission is to advance the field of biobanking in support of research relating to healthcare, agriculture and the environment. The focus is on Europe, the Middle East and Africa.
European Environment Agency
IPCHEM – The Information Platform for Chemical Monitoring

What is HBM4EU?

HBM4EU stands for “Human Biomonitoring for Europe”. The main aim of the initiative is to coordinate and advance human biomonitoring in Europe.

Who does HBM4EU consist of?

HBM4EU is a joint effort of 28 countries, the European Environment Agency and the European Commission, co-funded under Horizon 2020. The HBM4EU initiative represents a novel collaboration between scientists and chemical risk assessors and risk managers, including several Commission services, European agencies and national representatives. The project will build bridges between the research and policy worlds and deliver benefits to society in terms of enhanced chemical safety.

What is human biomonitoring?

People are exposed to a complex mixture of chemicals in their daily lives through the environment, consumer products, food and drinking water and at work. Human biomonitoring allows the measurement of exposure to chemicals by measuring either the substances themselves, their metabolites or markers of subsequent health effects in body fluids or tissues. Human biomonitoring provides a useful tool for assessing cumulative exposure to complex mixtures of chemicals. By collecting data from a representative sample of individuals under continuous surveillance programmes, health practitioners are able to evaluate the exposure of the general population to chemicals over time. Information on human exposure can be linked to data on sources and health effects, in order to inform research on exposure-response relationships in humans.

How will HBM4EU initiative work with human biomonitoring?

HBM4EU will use Human Biomonitoring to assess human exposure to chemicals in Europe, to better understand the associated health impacts and to improve chemical risk assessment. Despite the existence of human biomonitoring programmes at national level and the large number of research and development projects ongoing both at national and European Union level, there is a clear lack of data on aggregate exposure to single substances and to combinations of chemical substances, as well as insufficient evidence-based knowledge on the link between external exposure via different routes, internal levels and human health. This knowledge is essential to inform effective policy-making to protect the European population from the impacts of chemical exposure on health. HBM4EU will form a bridge between science and policy. Our research will explore current questions in chemical risk assessment and management and will deliver answers that help policy makers to protect human health. Policy makers, stakeholders and scientists will together shape the strategic direction of HBM4EU activities. This transparent and collaborative approach will ensure that our research generates knowledge that addresses genuine societal concerns.

What are the main objectives of HBM4EU?

- Harmonise procedures and tools for human biomonitoring at European Union level;
- Provide and, where missing, generate internal exposure data and link this data to external exposure and the relevant exposure pathways;
- Develop novel methods to identify human internal exposure to environmental and occupational chemicals and establish the causal links with human health effects;
- Provide policy-makers and the general public with science-based knowledge on the health risks associated with chemicals exposure; and
- Improve chemical risk assessment in the European Union through the effective use of human biomonitoring data.