A13_Phthalates case study: Use of HBM-GV (as in HBM4EU) compared to DNELinternal approach from ECHA’s RAC to perform risk characterisation

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Last Updated: 19-06-2019 8:08

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The focus is on describing the use, strengths and limitations of HBM data in an existing risk assessment, here the 4 phthalates restriction dossier under the REACH regulation. Under this restriction dossier, Risk Characterisation Ratios (RCRs) were calculated using the DNELinternal approach.
Another approach to calculate RCRs, making use of the HBM-GV derived within HBM4EU, is presented. Various factors might induce uncertainty when calculating RCRs based on HBM data, making the overall uncertainty very important to assess.